Rhodium-Catalyzed Asymmetric Hydroamination of Allyl Amines
2019
Vanable, Evan P. | Kennemur, Jennifer L. | Joyce, Leo A. | Ruck, Rebecca T. | Schultz, Danielle M. | Hull, Kami L.
A Rh-catalyzed enantioselective hydroamination of allylamines using a chiral BIPHEP-type ligand is reported. Enantioenriched 1,2-diamines are formed in good yields and with excellent enantioselectivities. A diverse array of nucleophiles and amine directing groups are demonstrated, including deprotectable motifs. Finally, the methodology was demonstrated toward the rapid synthesis of 2-methyl-moclobemide.
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