Lethality in mice of double-stranded ribonucleic acid from virus-like particles of Penicillium stoloniferum
1974
Sansing, G.A. | Lillehoj, E.B. | Freer, S.N. | Detroy, R.W.
The LD50 in mice of intact virus-like particles (VLP) from P. stoloniferum was >240 mg/kg and their component double-stranded RNA was 34 mg/kg. Administration of sublethal amounts of actinomycin D or cycloheximide simultaneously with sublethal amounts of intact VLP or mycoviral RNA enhanced lethality in mice.
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