High-Level Folate Production in Fermented Foods by the B₁₂ Producer Lactobacillus reuteri JCM1112
2008
Santos, Filipe | Wegkamp, Arno | Vos, Willem M. de | Smid, Eddy J. | Hugenholtz, J (Jeroen)
We observed that Lactobacillus reuteri JCM1112 produces B₁₂ and folate. However, the folate/B₁₂ mass ratio found was far below that desired for human consumption (~170:1). We used metabolic engineering applying genetic and physiological approaches to improve this ratio and developed a generic and natural process that significantly increases folate production.
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