Copper(I)/SaBOX catalyzed highly diastereo- and enantio-selective cyclopropanation of cis-1,2-disubstituted olefins with α-nitrodiazoacetates
2015
Feng, Liang-Wen | Wang, Peng | Wang, Lijia | Tang, Yong
A copper-catalyzed highly stereoselective cyclopropanation of 1,2-disubstituted olefins with α-nitro-diazo acetates has been developed, giving the desired products in up to 97% yields, up to >99/1dr and up to 98% ee, which provides an efficient access to the synthesis of optical active cyclopropane α-amino acids and unnatural α-amino acid derivatives.
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