Structure-activity relationships in photosystem II inhibition by 5-acyl-3-(1-aminoalkylidene)-4-hydroxy-2H-pyran-2,6(3H)-dione derivatives
1991
Yoneyama, K. | Nakajima, Y. | Konnai, M. | Iwamura, H. | Asami, T. | Takahashi, N. | Yoshida, S.
Quantitative structure-activity relationships in photosystem II (PS II) inhibition by 5-acyl-3-(1-aminoalkylidene)-4-hydroxy-2H-pyran-2,6(3H)-dione derivatives were analyzed. The results demonstrate that overall lipophilicity of the molecule is a major determinant for the activity as in the case for typical PS II inhibitors including phenylurea herbicides. In addition, the activity of the substituted N-benzyl derivatives was found to depend not only on the lipophilicity but also on both the electronic and steric characters of the substituents.
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