Nickel-Catalyzed Cross-Coupling of Aryl Fluorides and Organozinc Reagents
2014
Zhu, Feng | Wang, Zhong-Xia
Ni(PCy₃)₂Cl₂ was demonstrated to effectively catalyze cross-coupling of aryl fluorides and organozinc reagents. Both electron-poor and -rich aryl fluorides can react effectively with nucleophiles including aryl-, methyl-, and benzylzinc chlorides. A wide range of substituents and functional groups are tolerated. In the presence of a directing group, PhC(O), the reaction is selective for cleavage of the C–F bond ortho to the carbonyl substituent in a difluoroarene.
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