Antimicrobial polyethyleneimine-silver nanoparticles in a stable colloidal dispersion
2011
Lee, Hyun Ju | Lee, Se Guen | Oh, Eun Jung | Chung, Ho Yun | Han, Sang Ik | Kim, Eun-jung | Seo, Song Yi | Ghim, Han Do | Yeum, Jeong Hyun | Choi, Jin Hyun
Excellent colloidal stability and antimicrobial activity are important parameters for silver nanoparticles (AgNPs) in a range of biomedical applications. In this study, polyethyleneimine (PEI)-capped silver nanoparticles (PEI-AgNPs) were synthesized in the presence of sodium borohydride (NaBH₄) and PEI at room temperature. The PEI-AgNPs had a positive zeta potential of approximately +49mV, and formed a stable nanocolloid against agglomeration due to electrostatic repulsion. The particle size and hydrodynamic cluster size showed significant correlations with the amount of PEI and NaBH₄. PEI-AgNPs and even PEI showed excellent antimicrobial activity against Staphylococus aureus and Klebsiella pneumoniae. The cytotoxic effects of PEI and PEI-AgNPs were confirmed by an evaluation of the cell viability. The results suggest that the amount of PEI should be minimized to the level that maintains the stability of PEI-AgNPs in a colloidal dispersion.
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