Bactericidal activites of selected macrofungi extracts against Staphylococcus aureus
Nikolovska-Nedelkoska, Daniela A. | Atanasova-Pančevska, Natalija V. | Karadelev, Mitko P. | Kungulovski, Džoko V.
The increasing of the antibiotic resistance exhibited by pathogenic microorganisms has resulted in research directed toward evaluation of novel sources of antimicrobial compounds. Previous studies have indicated that macrofungi, as a specific response to the natural hostile environment, produce secondary metabolites with antimicrobial properties. In this study, antimicrobial activities of the extracts from six wild mushrooms: Amanita echinocephala, Russula medulata, Cerena unicolor, Hericium erinaceus, Ishnoderma benzoinum and Laetiporus sulphureus were evaluated against Grampositive bacterium Staphylococcus aureus. The antimicrobial potential of the methanolic mushroom extracts was investigated by the microdilution method. Antimicrobial activity was observed in all species included in the study. All the extracts that demonstrated inhibitory activities were further tested for bactericidal activity and minimum bactericidal concentration (MBC) values were determined. The tested microorganism was most sensitive to the examined extracts from the polypore fungi C. unicolor and H. erinaceus. The highest bactericidal activity was obtained in the extracts from the species C. unicolor (MBC=1.563 mg/mL). The experimental results revealed that the methanolic extract of C. unicolor possessed significant bactericidal activity. The findings suggest the potential use of this wild mushroom as antimicrobial agent.
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