Synthesis and antimicrobial activity of 6-triazolo-6-deoxy eugenol glucosides
2015
de Souza, Thiago Belarmino | Raimundo, Paulo Otávio Botelho | Andrade, Saulo Fernandes | Hipólito, Taciane Maira Magalhães | Silva, Naiara Chaves | Dias, Amanda Latercia Tranches | Ikegaki, Masaharu | Rocha, Raissa Prado | Coelho, Luiz Felipe Leomil | Veloso, Marcia Paranho | Carvalho, Diogo Teixeira | Dias, Danielle Ferreira
A new series of 1,2,3-triazole eugenol glucosides were synthesized. The new compound structures were confirmed by MS, ¹H NMR and ¹³C NMR. All of the synthesized compounds were screened for antimicrobial and cytotoxic activity. Five compounds exerted significant activity against the Gram-negative bacteria Salmonella typhimurium with low IC50 values (49.73–68.53 μΜ), and seven compounds were active against the Gram-positive bacteria Micrococcus luteus (42.89–210.94 μM). In vitro cytotoxicity on mouse spleen cells was also evaluated. One compound bearing a phenyl substituent at the triazole ring showed good activity against Salmonella typhimurium (49.73 μM) and low toxicity to normal cells (CC50=157.83 μM). Thus, the compounds herein can be considered for further modification for improving their antibacterial activity or obtaining novel antibacterial drug candidates.
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