Retrograded high-amylose corn starch reduces cholic acid excretion from the small bowel in ileostomy subjects
1998
Langkilde, A.M. | Ekwall, H. | Bjorck, I. | Asp, N.G. | Andersson, H.
Objective: To study the short-term effect of resistant starch (RS) from retrograded high-amylose corn starch (HACS) on the excretion of bile acids and nutrients from the small bowel in humans. Design: Seven healthy ileostomists were given a controlled, constant diet during three days. On days 2 and 3, 100 g/d of one of two test-product--drum-dried ordinary corn starch and autoclaved retrograded HACS, providing 5 and 39 g RS/d, respectively--was given, in random order. Ileostomy effluents were collected for 24 h per day and analysed for wet weight, dry weight, energy, bile acids and nutrients. Settings: In-patient study at the metabolic ward, Department of Clinical Nutrition, Sahlgrenska University Hospital, Goteborg. Results: Consumption of retrograded HACS caused (1) a 42% lower mean excretion of cholic acid (P = 0.024); (2) a 42% lower mean wet weight concentration of bile acids (P < 0.001); (3) a 70% increased excretion of dry weight (P = 0.001); and (4) a 41% increased excretion of energy (P = 0.036) compared with consumption of drum-dried ordinary corn starch. Conclusion: The reduced ileal excretion and concentration of cholic acid would be protective regarding colon cancer risk in addition to the increased fermentation substrate provided by RS and other energy-yielding components.
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