Prophylactic effects of recombinant bovine interferon -alpha 1 on acute Salmonella typhimurium infection in calves

Peel, J.E.; Kolly, C.; Siegenthaler, B.; Martinod, S.R.

Prophylactic effects of recombinant bovine interferon -alpha 1 on acute Salmonella typhimurium infection in calves

1990

Peel, J.E. | Kolly, C. | Siegenthaler, B. | Martinod, S.R.

The in vivo effects of a single prophylactic dose of recombinant bovine interferon (rBoIFN)-alphaI1 in calves with salmonellosis were investigated, using a Salmonella typhimurium infection model. Treatment with rBoIFN-alphaI1 reduced the degree of septicemia compared with that in control groups, and, in one experiment, using disease of reduced severity, body temperature was lower in treated calves than in controls.

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