Effect of Green Tea and Vitamin E Combination in Isoproterenol Induced Myocardial Infarction in Rats
2009
Upaganlawar, Aman | Gandhi, Chintan | Balaraman, Ramchandran
The present study was aimed to investigate the combined effects of green tea and vitamin E on heart weight, body weight, serum marker enzymes, lipid peroxidation, endogenous antioxidants and membrane bound ATPases in isoproterenol (ISO)-induced myocardial infarction in rats. Adult male albino rats, treated with ISO (200 mg/kg, s.c.) for 2 days at an interval of 24 h caused a significant (P < 0.05) elevation of heart weight, serum marker enzymes, lipid peroxidation and Ca⁺² ATPase level whereas there was a significant (P < 0.05) decrease in body weight, endogenous antioxidants, Na⁺/ K⁺ ATPase and Mg⁺² ATPase levels. Administration of green tea (100 mg/kg/day, p.o.) and vitamin E (100 mg/kg/day, p.o.) together for 30 consecutive days and challenged with ISO on the day 29th and 30th, showed a significant (P < 0.05) decrease in heart weight, serum marker enzymes, lipid peroxidation, Ca⁺² ATPase and a significant increase in the body weight, endogenous antioxidants, Na⁺/K⁺ ATPase and Mg⁺² ATPase when compared with ISO treated group and green tea or vitamin E alone treated groups. These findings indicate the synergistic protective effect of green tea and vitamin E during ISO induced myocardial infarction in rats.
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