Cytotoxicity of isoflavones from Millettia dura
Buyinza, Daniel | Yang, Li Jun | Derese, Solomon | Ndakala, Albert | Coghi, Paolo | Heydenreich, Matthias | Wong, Vincent Kam Wai | Möller, Heiko M. | Abiy Yenesew,
The first phytochemical investigation of the flowers of Millettia dura resulted in the isolation of seven isoflavones, a flavonol and a chalcone. Eleven isoflavones and a flavonol isolated from various plant parts from this plant were tested for cytotoxicity against a panel of cell lines, and six of these showed good activity with IC₅₀ values of 6-14 μM. Durmillone was the most active with IC₅₀ values of 6.6 μM against A549 adenocarcinomic human alveolar basal epithelial cancer cell line with low cytotoxicity against the non-cancerous cell lines BEAS-2B (IC₅₀ = 58.4 μM), LO2 hepatocytes (IC₅₀ 78.7 μM) and CCD19Lu fibroblasts (IC₅₀ >100 μM).
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