Khaya grandifoliola C. DC. (Meliaceae: Sapindales): Ethnobotany, phytochemistry, pharmacological properties, and toxicology

Khaya grandifoliola is a well-known tree species in Africa with a conservation status of ‘vulnerable’ due to its overexploitation by the wood industry. Several studies have recorded numerous ethnobotanical uses of this plant, as well as the scientific validation of the efficacy of extracts from different plant parts used for the treatment of various ailments. However, this useful information is scattered throughout the literature and thus there is no opportunity to identify the existing knowledge gaps.This review aims to highlight the medicinal importance of Khaya grandifoliola including its known phytochemistry, biological activities and toxicology, to encourage a refocused conservation strategy since all current efforts are geared towards maintaining its continuous supply to the wood industry.Articles on K. grandifoliola were sourced from online databases such as Google Scholar, Medicine, PubMed, Science Direct, Scopus, SciFinder and other science journal websites up to May 2020. The search was conducted using various combinations of keywords such as biotechnological uses, biological activity, ethnobotany, ethnomedicine, indigenous uses, pharmacological activity, phytochemistry, proximate composition, toxicity, and traditional uses of K. grandifoliola. All downloaded articles were screened to determine their relevance to the scope of the review and the selected papers were included.The review revealed a host of ethnomedicinal uses such as anticancer, antidiabetic, antimicrobial, anti-sickling, anti-ulcerogenic, and hepatoprotective, many of which are supported by scientific data. More importantly, toxicity tests revealed that many of the extracts are safe at various therapeutic doses. Important knowledge gaps that should be explored include phytochemical characterization and validation of some ethnobotanical claims on the folkloric usage of the plant.Notwithstanding the importance of K. grandifoliola in the wood industry, this review reveals that its use as a medicine is equally important. Its medicinal uses are also well supported with scientific studies as well as favourable toxicological studies though some scientific knowledge gaps require further studies.