A new flavonoid glycoside from Tapinanthus sp. (Loranthaceae) and evaluation of anticancer activity of extract and some isolated compounds
2022
Gade, Isaac Silvère | Chadeneau, Corinne | Richard, Tagne Simo | Atchade, Alex De Théodore | Talla, Emmanuel | Seite, Paul | Vannier, Brigitte | Guillard, Jérôme | Laurent, Sophie | Henoumont, Celine | Nwabo, Armel H Kamdje | Muller, Jean-Marc
The present work describes the isolation and anticancer activity of Tapinanthus sp. which is a hemi parasitic plant harvested on Combretum glutinosum, the host plant. Phytochemical study afforded a new flavonoid glycoside, tapinantoside (1) isolated for the first time from natural source, alongside six known compounds (2-7). Structure of compounds were elucidated by extensive spectroscopic analyses including 1 D and 2 D NMR, mass spectrometry and by comparison with literature data. The anticancer activity of extract and some isolated compounds were evaluated on glioblastoma (U87MG, C6) and prostate (PC-3) cancer cells. The methanol leaves extract showed good anticancer activity against U87 (IC₅₀ = 21.40 µg/mL) and PC-3 cells (IC₅₀ = 10.26 µg/mL). Compound 3 powerfully inhibits the proliferation of C6 (IC₅₀ = 38.84 µM) and PC-3 cells (IC₅₀ = 21.33 µM), while its effect was moderated on U87MG cells. Compound 1 and 7 were not active on all tested cancer cell lines.
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