Effect of kauranes from Montanoa spp. on rat uterus
1997
CamposâBedolla, Patricia | Campos, María G. | ValenciaâSánchez, Antonio | PonceâMonter, Héctor | Uribe, Carmen | Osuna, Lidia | Calderón, J.
The effect of kaurenoic acid (from Montanoa frutescens), grandifloric and kauradienoic acid (from M. tomentosa) and 16αâhydroxyâentâkauranâ19âoic acid and its methyl ester (from M. hibiscifolia) were assayed on the contractions of rat uterus induced by acetylcholine, oxytocin and serotonin. The four kauranes assayed inhibited the contractile activity induced by the three agonists through a mechanism independent of either β2âadrenergic or H2âhistaminergic receptors present in uterine smooth muscle. Oestrogenized uteri treated with kauradienoic acid underwent histological changes including epithelial flattening and desquamation.© 1997 John Wiley & Sons, Ltd.
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