Hydration of acrylonitrile to produce acrylamide using biocatalyst in a membrane dispersion microreactor
2014
Li, Jiahui | Chen, Jie | Wang, Yujun | Luo, Guangsheng | Yu, Huimin
In this work, a membrane dispersion microreactor was utilized for the hydration of acrylonitrile to produce acrylamide. Through observation using a microscopy, it was found that the acrylonitrile was dispersed into the continuous phase (the aqueous phase contains nitrile hydratase (NHase)) as droplets with a diameter ranged from 25 to 35μm, hence the mass transfer specific surface area was significantly increased, and the concentration of acrylamide reached 52.5wt% within 50min. By contrast, in stirred tanks, the concentration of acrylamide only got 39.5wt% within 245min. Moreover, only a few amounts of acrylonitrile were accumulated in this microreactor system. Through optimizing the flow rate, the concentration of acrylamide reached 45.8wt% within 35min, the short reaction time greatly weakened the inhibition of acrylonitrile and acrylamide on the enzyme activity, which is suitable for prolonging the life of free cell.
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