A general, enantioselective synthesis of 2-substituted thiomorpholines and thiomorpholine 1,1-dioxides
2019
Reed, Carson W. | Lindsley, Craig W.
In the course of our drug discovery programs, we had need to access chiral, 2-substituted thiomorpholines and their oxidized congeners, thiomorpholine 1,1-dioxides. Here, we disclose a high-yielding, general protocol for the enantioselective synthesis of C2-functionlized thiomorpholines and thiomorpholine 1,1-dioxides.
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