Pd-catalyzed cyanation of benzyl chlorides with nontoxic K₄[Fe(CN)₆]
2011
Ren, Yunlai | Yan, Mengjie | Zhao, Shuang | Sun, Yanpei | Wang, Jianji | Yin, Weiping | Liu, Zhifei
Non-toxic K₄[Fe(CN)₆] was demonstrated to be effective as a green cyanating agent for the cyanation of alkyl halides using PPh₃/Pd(OAc)₂ as a catalyst system. The presented method allowed a series of benzyl chlorides to be smoothly cyanated in up to 88% yield. In order to avoid or suppress the deactivation of the catalyst, the reaction was required to be performed in a stringent inert ambiance.
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