(NH₄)₂S₂O₈-Mediated Metal-Free Decarboxylative Formylation/Acylation of α-Oxo/Ketoacids and Its Application to the Synthesis of Indole Alkaloids
2022
Dinesh, Votarikari | Nagarajan, R. (Rajagopal)
A metal-free method for the formylation/acylation of indoles and β-carbolines with (NH₄)₂S₂O₈ via direct decarboxylative cross-coupling of α-oxo/ketoacids in moderate to good yields is described. The reaction occurs between ambient temperature and 40 °C under mild reaction conditions with commercially available starting materials. This methodology can be expanded to some biologically active indole alkaloids like pityriacitrins, eudistomins Y₁ and Y₃, and marinacarbolines A–D.
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