Bile acid metabolism in ascorbic acid-deficient guinea pigs
1979
(William S.)
Guinea pigs were used to determine the effects of ascorbic acid (AA) deprivation on hepatic steroid metabolism. A carefully controlled diet maintained food intake and body weight. Fecal excretion rates on neutral steroids and bile acids were measured and compared before and 10-14 days after AA withdrawal. The size of the bile acid pool was measured as well as cholesterol 7 alpha-hydroxylase activity in the early stages. Bile acid metabolism was significantly reduced by the lack of AA. Bile acid pool and excretion rates declined about 50%. Biosynthetic activity in the liver was reduced, though the enzymatic role of cholesterol 7 alpha-hydroxylase is not fully understood. Serum cholesterol levels, though variable, were not significantly altered. Serum triglyceride rose 46%.
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