Isolation of antitumor alkaloids from Cephalotaxus harringtonia
1974
Powell, R.G. | Rogovin, S.P. | Smith, C.R. Jr
Purified antitumor alkaloids (harringtonine. isoharringtonine, and homoharringtonine) from Cephalotaxus harringtonia have been isolated in the pilot plant. Major processing steps included extraction of the plant material with ethanol, isolation of a crude alkaloid fraction by chloroform extraction. preliminary separation of the crude alkaloids by 10-tube countercurrent distribution, concentration of the active alkaloids by column chromatography, and final separation of the active alkaloids by 200-tube countercurrent distribution. From 455 kg of plant material. about 330 g of crude alkaloid was obtained which yielded 36 g of three purified active cephalotaxine esters.
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