Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack
2021
Amelia, Puteri | Nugroho, Alfarius Eko | Hirasawa, Yusuke | Kaneda, Toshio | Tougan, Takahiro | Horii, Toshihiro | Morita, Hiroshi
Two new bisindole alkaloids, bisnaecarpamines A (1) and B (2), possessing a vobasine-sarpagine type skeleton were isolated from the bark of Tabernaemontana macrocarpa Jack. Their structures were elucidated by extensive spectroscopic methods and chemical correlation. The absolute configurations of compounds 1 and 2 were established using TDDFT-ECD calculation of the selected isomers. Bisnaecarpamine A exhibited potent antimalarial activity against Plasmodium falciparum 3D7 strain with IC₅₀ value of 28.8 µM.
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