Polydopamine-Coated Magnetic Composite Particles with an Enhanced Photothermal Effect
2015
Zheng, Rui | Wang, Sheng | Tian, Ye | Jiang, Xinguo | Fu, Deliang | Shen, Shun | Yang, Wuli
Recently, photothermal therapy (PTT) that utilizes photothermal conversion (PTC) agents to ablate cancer under near-infrared (NIR) irradiation has attracted a growing amount of attention because of its excellent therapeutic efficacy and improved target selectivity. Therefore, exploring novel PTC agents with an outstanding photothermal effect is a current research focus. Herein, we reported a polydopamine-coated magnetic composite particle with an enhanced PTC effect, which was synthesized simply through coating polydopamine (PDA) on the surface of magnetic Fe₃O₄ particles. Compared with magnetic Fe₃O₄ particles and PDA nanospheres, the core–shell nanomaterials exhibited an increased NIR absorption, and thus, an enhanced photothermal effect was obtained. We demonstrated the in vitro and in vivo effects of the photothermal therapy using our composite particles and their ability as a contrast agent in the T₂-weighted magnetic resonance imaging. These results indicated that the multifunctional composite particles with enhanced photothermal effect are superior to magnetic Fe₃O₄ particles and PDA nanospheres alone.
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