Antioxidant enzyme response studies in h₂o₂-stressed porcine muscle tissue following treatment with fava bean sprout extract and l-dopa
2006
RANDHIR, REENA | Vattem, Dhiraj A. | Shetty, Kalidas
Readily absorbed fava bean sprout extract (FSE), rich in levo-dihydroxy phenylalanine (L-DOPA) and a high total phenolic content, as well as synthetic L-DOPA countered oxidative stress caused by H₂O₂ through stimulation of an antioxidant enzyme response in porcine muscle tissue. Evidence suggests that the phenolic treatments such as FSE had a protective effect on the stressed porcine muscle by maintaining the cellular redox homeostasis, through modulation of the cellular antioxidant enzymes such as superoxide dismutase, catalase and total peroxidase via enhanced pentose phosphate pathway (PPP) through stimulation of glucose-6-phosphate dehydrogenase (G6PDH) resulting in higher NADPH (reduced nicotinamide adenine dinucleotide phosphate). A marked increase in proline content was observed in the case of FSE and L-DOPA treatments both under stressed and unstressed conditions indicating an interface to proline-linked PPP. The major implication from this study is the evidence that FSE and L-DOPA have direct roles as quenchers of free radicals and also as potential modulators of the endogenous cellular antioxidant enzyme response with L-DOPA in a natural fava bean background being more protective and stable.
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