Extrachromosomal elements cause a reduced division potential in nib1 strains of Saccharomyces cerevisiae
1989
Sweeney, R. | Zakian, V.A.
The nib 1 allele of yeast confers a sensitivity to an endogenous plasmid, 2 microns DNA, in that nib 1 strains bearing 2 microns DNA (cir+) exhibit a reduction in division potential. In the present study, the reduction in division potential characteristic of nib 1 cir+ strains is shown to be dependent on the simultaneous presence of both the A and the D open reading frames of 2 microns DNA as well as on the presence of an unidentified extrachromosomal element other than 2 microns DNA. Futhermore, in nib 1 strains, an uncharacterized extrachromosomal element can cause a less severe reduction of division potential in the absence of intact 2 microns DNA. Thus, the nib 1 allele may confer a generalized sensitivity to extrachromosomal elements.
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