Changes in CREB (SER133) Content and DNA-Binding Activity of Transcriptional Factors in Rat Brain Cells against the Background of Ladasten Exposure
2009
Salimgareeva, M. Kh | Vakhitova, Yu. V | Yamidanov, R. S | Sadovnikov, S. V | Seredenin, S. B
We studied the effects of single administration of ladasten (50 mg/kg) on the level of transcriptional factor CREB (cyclic AMP response binding element protein) phosphorylated by Ser133 in rat striatum, hypothalamus, and hippocampus. Transcriptional factors with affected DNA-binding activity were identified in brain cells.
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