Strychnos potatorum Linn Seed Extract Enhances Lysosomal Membrane Stability and Collagen Formation in Freunds Complete Adjuvant-Induced Arthritic Rats
2011
Ekambaram, Sanmuga Priya | Perumal, Senthamil Selvan | Subramanian, Venkataraman
The effect of the aqueous extract (SPE) and powder (SPP) of S. potatorum seeds at the dose of 200 mg.kg⁻¹ p.o. were studied in developing and developed stages of Freunds adjuvant (0.1mL) induced arthritic rats for 14 and 28 days respectively. On day 29, the animals were sacrificed and serum and tissue samples were collected for estimation of lysosomal enzymes, glycoproteins and angular cartilage for collagen formation. In both stages of arthritis, the serum and tissue levels showed increased lysosomal enzymes and glycoproteins whereas decreased collagen content in the synovial tissues. SPP and SPE treatment to the arthritic rats normalized the lysosomal enzymes and glycoproteins and increased the collagen content, which may be due to its membrane-stabilizing action and suppression of the collagenases that destroys collagen and bone.
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