Meroindenon and Merochlorins E and F, Antibacterial Meroterpenoids from a Marine-Derived Sediment Bacterium of the Genus Streptomyces
2019
Ryu, Min-Ji | Hwang, Sunghoon | Kim, Sojeong | Yang, Inho | Oh, Dong-Chan | Nam, Sang-Jip | Fenical, William
Meroterpenoids, meroindenon (1) and merochlorins E (2) and F (3), were isolated from a marine-derived bacterium belonging to the genus Streptomyces. Their chemical structures were established using extensive analysis of MS, UV, ECD, and NMR spectroscopic data. Compounds 1–3 possess a tetrahydroxynaphthalene core and a C₁₅-isoprene unit. Compounds 2 and 3 exhibited strong antibacterial activities against B. subtilis, K. rhizophila, and S. aureus, with a range of MIC values from 1 to 2 μg/mL.
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