Physiological Parameters of Thrombocytes in Piglets during the Plant Nutrition Phase in Early Ontogenesis
2019
Zavalishina, S. Yu | Tkacheva, E. S.
Platelet hemostasis is a very important mechanism of maintaining homeostasis in animals. Its activity level determines the blood rheology in capillaries and the tissue metabolism. Piglets’ growth and development depend on the platelets’ level of functional activity. For this reason, studies into the age-related dynamics of platelet activity in piglets at the end of early ontogenesis are of great importance. It was found that the piglets on plant nutrition showed an increase in the platelets’ aggregation capacity (aggregation of their platelets was accelerated by ADP from 34.1 ± 0.12 s to 27.6 ± 0.12 s, from 24.7 ± 0.08 s to 17.5 ± 0.10 s with collagen, from 36.5 ± 0.08 s to 28.4 ± 0.12 s with thrombin). Intensification of the work of platelets’ receptor and postreceptor mechanisms is the main reason for this effect. The main cause of the revealed increase in platelets’ activity in piglets was the increased thromboxane synthesis (from 48.5 ± 0.05 to 59.8 ± 0.09%). The latter, in turn, was largely due to an increase in the activity of cyclooxygenase (from 78.4 ± 0.06 to 89.8 ± 0.12%) and thromboxane synthetase (from 69.2 ± 0.07 to 81.5 ± 0.07%) and activation of ADP secretion (from 46.0 ± 0.13 to 56.9 ± 0.15%).
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