Synthesis of tetra-substituted pyrroles, a potential phosphodiesterase 4B inhibitor, through nickel(II) chloride hexahydrate catalyzed one-pot four-component reaction
2012
Khan, Abu T. | Lal, Mohan | Ray Bagdi, Prasanta | Sidick Basha, R. | Saravanan, Parameswaran | Patra, Sanjukta
A wide variety of tetra-substituted pyrrole derivatives were synthesized through one-pot four-component condensation reaction of aromatic aldehydes, benzylamines, β-ketoesters, and nitroalkanes in the presence of 10mol% NiCl₂·6H₂O in good yields. Some of them exhibit properties as potential inhibitors of phosphodiesterase 4B (PDE4B) through docking studies.
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