Highly regioselective ring-opening of epoxides with amines: a metal- and solvent-free protocol for the synthesis of β-amino alcohols
2020
Li, Dong | Wang, Jing | Yu, Shibo | Ye, Silei | Zou, Wenjie | Zhang, Hongbin | Chen, Jingbo
We herein report a metal- and solvent-free acetic acid-mediated ring-opening reaction of epoxides with amines. This process provides β-amino alcohols in high yields with excellent regioselectivity. Importantly, this epoxide ring-opening protocol can be used for the introduction of amines in natural products during late-stage transformations.
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