Maintenance requirements for copper in adult male mice fed AIN-93M rodent diet
1994
Reeves, Philip G. | Rossow, Kerry L. | Johnson, LuAnn
Adult male Swiss-Webster mice were fed diets similar to AIN-93M containing 0.8, 1.7, 2.5, 3.6, 4.3, 5.4, and 6.5 mg copper/kg. Significant reductions in serum copper, serum ceruloplasmin amine oxidase activity, and liver copper concentrations were observed in mice fed dietary copper concentrations lower than 2.5 mg/kg. By using nonlinear modeling of serum copper concentrations and serum ceruloplasmin amine oxidase activity, it was estimated that the minimal dietary concentration of copper to maintain maximal levels of these parameters in adult male mice was between 2.5 and 4 mg/kg diet.
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