Influence of vehicle on kinetics of exogenous progesterone administered either by subcutaneous and intramuscular routes to sheep
Contreras-Solis, I. | Gomez-Brunet, A. | Encinas, T. | Gonzalez-Bulnes, A. | Santiago-Moreno, J. | Lopez-Sebastian, A.
This study aimed to determine the best vehicle and administration route for progesterone administration in sheep. In a first replicate, single intramuscular doses of 25 mg progesterone were administered to ewes previously ovariectomized, either in propylene glycol (group IM-PG, n = 6) or olive oil (group IM-OO, n = 5). In a second replicate, the same solutions of progesterone were administered subcutaneously to the same ewes (groups SC-PG, n = 6, and SC-OO, n = 5). In the present study, the best pharmacokinetic results of a single dose of 25 mg of progesterone were obtained, both using PG and OO as vehicles, by the subcutaneous route. Thus, progesterone remained in plasma for a longer time after subcutaneous administration in PG than in OO (t1/2β: 60.65 ± 13.07 vs. 27.51 ± 3.59 h; P < 0.05); the mean residence time being higher in SC-PG than in SC-OO group (88.99 ± 18.36 vs. 41.04 ± 5.31 h; P < 0.05). However, both vehicles allowed maintained plasma levels 0.5 ng/ml for at least 30 h, so any of these treatments may be efficiently used for administration of exogenous progesterone.
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