Hypercholesterolemia in mice with meat anemia
Jacob, R.A. | Baesler, L.G. | Klevay, L.M. | Lee, D.E. | Wherry, P.L.
Meat anaemia, a disease which occurs in mice eating an all-meat diet, has been characterized as being due to the low-calcium content and high ratio of Zn:Cu of the meat diet (NAR 35, 703). Of 79 male Swiss mice 48 were given beef sirloin with Zn:Cu ratio 57, and 31 were given 3 parts sirloin to 1 part beef liver so that Zn:Cu ratio was 4. They ate about 7.5 g daily. Blood was collected after 8 weeks and the mice were killed after 62 days. After 8 weeks mortality in those on sirloin was 54% and in those on sirloin and liver was 3%. Haematocrit was 24.5 and 55.4% and plasma cholesterol 121.1 and 96.3 mg/100 ml. Plasma cholesterol was correlated negatively with haematocrit. It has been suggested that an imbalance of Zn to Cu is a factor in the causation of coronary heart disease.
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