Identification of secreted virulence factors of Chromobacterium violaceum
Castro-Gomes, Thiago | Cardoso, Mariana S. | DaRocha, Wanderson D. | Laibida, Letícia A. | Nascimento, Andréa M. A. | Zuccherato, Luciana W. | Horta, Maria Fátima | Bemquerer, Marcelo P. | Teixeira, Santuza M. R.
Chromobacterium violaceum, a component of tropical soil microbiota, is an opportunistic pathogenic bacterium that can infect humans and other animals. In addition to identifying a large number of genes that demonstrate the vast biotechnological potential of this bacterium, genome sequencing revealed several virulence factors, including different cytolysins, which can be related to its pathogenicity. Here we confirmed these predictions from genomic analyses by identifying, through mass spectrometry, proteins present in the culture supernatant of C. violaceum that may constitute secreted virulence factors. Among them, we identified a secreted collagenase and the product of a gene with sequence similarity to previously characterized bacterial porins.
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