Protein tyrosine phosphatases: regulatory mechanisms
2008
Hertog, Jeroen den | Östman, Arne | Böhmer, Frank-D.
Protein-tyrosine phosphatases are tightly controlled by various mechanisms, ranging from differential expression in specific cell types to restricted subcellular localization, limited proteolysis, post-translational modifications affecting intrinsic catalytic activity, ligand binding and dimerization. Here, we review the regulatory mechanisms found to control the classical protein-tyrosine phosphatases.
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