Cytotoxic sesquiterpene lactones from Artemisia anomala
2017
Li, Lu | Liu, Hongchun | Tang, Chunping | Yao, Sheng | Ke, Changqiang | Xu, Chenghui | Ye, Yang
Two new sesquiterpene lactones, 8α-acetoxy-1,10α-epoxy-2-oxo-guaia-3,11(13)-dien-12,6α-olide (1) and 13-acetoxy-1-oxo-4α-hydroxy-eudesman-2(11)-dien-12,6α-olide (2), along with six known analogs (3-8), were isolated from the whole plant of Artemisia anomala S. Moore. Their structures were elucidated by extensive analysis of spectroscopic data. Compounds 6 and 7 exhibited in vitro moderate cytotoxicity against A549 cells with IC50 values of 0.6 and 0.9μM, and HepG2 cells with IC50 values of 5.4 and 3.0μM, respectively.
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