Chromium III Exposure Inhibits Brain Na⁺K⁺ATPase Activity of Clarias batrachus L. Involving Lipid Peroxidation and Deficient Mitochondrial Electron Transport Chain Activity
2009
Maiti, A. K. | Paul, G. | Maity, B. | Mazumdar, D. | Saha, N. C.
The present study elucidated the role of lipid peroxidation and diminished mitochondrial electron transport chain activity in partial dysfunction of brain Na⁺K⁺ATPase of Clarias batrachus exposed to chromium III ions. The fish were exposed to 10% and 20% of the derived 96 h LC₅₀ value, 5.69 mg/L and 11.38 mg/L, respectively, and sampled on 20, 40 and 60 days. Exposure to chromium III on fish brain demonstrated an increased lipid peroxidation, production of protein carbonyl and reactive oxygen species and loss of protein thiol groups in synaptosomal fraction with decreased activity of Na⁺K⁺ATPase, partial inactivation of mitochondrial electron transport chain activity and energy depletion.
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