Effets de l’hyperlipidémie sur la qualité embryonnaire et les résultats de la fécondation in vitro chez des femmes tunisiennes infertiles
2015
Chaouache, Nesrine | Ajina, Mounir | Gaddas, Mariem | Miled, Abdelhedi | Tabka, Zouhair | Zbidi, A. (Abdelkrim) | Zaouali-Ajina, Monia
The importance of maternal metabolic environment for a correct embryonic development has not been well explored until now. The objective of our work is to determine the metabolic profile impact on biological results of assisted reproductive technology (ART) in infertile women of different weights.Forty patients undergoing ART cycles were divided into three groups (control group, overweight group and obese group) according to the body mass index. Blood samples were measured on the day of oocyte retrieval for biochemical analyses of glucose, total cholesterol, triglycerides and High-density lipoprotein. The biological parameters measured were: total number of oocytes, number of zygotes, oocyte quality, embryo quality, and fertilization and segmentation rates.Disturbances in metabolic profile were found in obese women accompanied by poor reproductive outcomes, compared to other groups. Hypertriglyceridemia found in the obese group was negatively correlated with embryo quality (r=0.33; P=0.037) and fertilization rate (r=0.3; P=0.048). High glucose and cholesterol levels were accompanied by poor oocyte maturity, poor embryo quality and a low fertilization rate.In conclusion, evidence has been shown to suggest that hypertriglyceridemia, high cholosterol, and high glycemia levels in obese women have a negative effect on the success of in vitro fertilization. As such, appropriate nutritional care and metabolic syndrome screening could improve the ART result among obese.
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