Importance of a pyrogallol-type structure in catechin compounds for apoptosis-inducing activity
2000
Saeki, K. | Hayakawa, S. | Isemura, M. | Miyase, T.
Several catechin compounds were examined for their ability to induce apoptosis in human hystiocytic lymphoma U937 cells. Catechins with a pyrogallol-type structure in a B-ring induced apoptosis and a 3-O-gallate group in cis-relationship to the B ring enhanced the activity. Catechins without a pyrogallol-type structure in a molecule lacked activity. These data suggest the important role of the 5'(3')-hydroxyl group in the B-ring and that a pyrogallol-type structure in a molecule is a minimum requirement for apoptosis induction by catechin compounds.
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