Subchronic toxicity studies of SALATRIM structured triacylglycerols in rats. 3. Triacylglycerols composed of stearate, acetate, propionate, and butyrate
Hayes, J.R. | Wilson, N.H. | Pence, D.H. | Williams, K.D.
SALATRIM 234CS lot A018 and SALATRIM 234CA lot A019 are structured triacylglycerols having lower caloric availability (4.5-6.0 kcal/g) than corn oil (9.0 kcal/g). Rats were fed both SALATRIM fats at 2%, 5%, and 10% or corn oil at 10% in the diet for 13 weeks. Body weight and feed consumption varied predictably with caloric density of the diets. Ophthalmologic observations, serum and liver concentrations of fat-soluble vitamins, clinical pathology, organ weights, and necropsy findings were unaffected by treatment. Small variations in bone mineral concentrations of 10% SALATRIM and corn oil rats were considered to be related to the levels of unsaturated fatty acids in these diets. A slightly increased incidence of renal mineralization was noted in mid- and high-dose SALATRIM 234CA lot A019 and SALATRIM 234CS lot A018 females. This finding was considered to be possibly related to a general mineral effect indicated by the changes in bone minerals. Overall, neither SALATRIM fat produced biologically significant effects.
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