Aflatoxins and fumonisins in corn from the high-incidence area for human hepatocellular carcinoma in Guangxi, China
2001
Li, F.Q. | Yoshizawa, T. | Kawamura, O. | Luo, X.Y. | Li, Y.W.
A comparative study on the natural occurrence of aflatoxins and Fusarium toxins was conducted with corn samples from high- and low-incidence areas for human primary hepatocellular carcinoma (PHC) in Guangxi, China. In samples from the high-risk area, aflatoxin B1 was the predominant toxin detected in terms of quantity and frequency, with its concentration ranging between 9 and 2496 microgram/kg and an 85% incidence of contamination. Among the samples, 13 (76%) exceeded the Chinese regulation of 20 microgram/kg for aflatoxin B1 in corn and corn-based products intended for human consumption. Significant differences in aflatoxin B1, B2, and G1 and total aflatoxin concentrations in corn between the areas were found (P < 0.05). The average daily intake of aflatoxin B1 from corn in the high-risk area was 184.1 microgram, and the probable daily intake is estimated to be 3.68 microgram/kg of body weight/day, 3.20 times the TD50 in rats. Corn samples from both areas were simultaneously contaminated with fumonisins B1, B2, and B3. Aflatoxin B1 may play an important role in the development of PHC in Guangxi.
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