The toxicity of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to Periplaneta americana L. and its effects on dopamine in the cerebral ganglia
1991
Owen, M.D.
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and MPP+ (1-methyl-4-phenylpyridinium ions) are potent dopaminergic neurotoxins in mammals. The mammalian toxicity of MPTP depends on its conversions, by monoamine oxidase, to MPP+. MPTP is toxic to cockroaches (LD50 720 micrograms gm-1) and the results suggest that MPTP toxicity depends on monoamine oxidase activity at a site outside the nervous system. MPTP depletes dopamine from cockroach cerebral ganglia and MPP+ inhibits cockroach mitochondrial respiration. While the biochemistry of MPTP toxicity appears to be the same as in mammals it seems that insects are unable to detoxify MPTP before its action has fatal consequences outside the nervous system.
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