Peripheral neurotoxicity of cadmium in growing rats: preventive role of vitamin E
1991
Murthy, R.C. | Gupta, A. | Gupta, A. | Anand, M. | Chandra, S.V.
The effect of daily intraperitoneal administration of cadmium (0.4 mg/kg) to growing rats for 30 days on the peripheral neurotoxicity was investigated by using gastrocnemius sciatic nerve preparation and certain biochemical parameters. Further, the effect of vitamin E (5 mg/kg) administration on alternate days on the cadmium induced changes in the peripheral nervous system was also studied. Cadmium was found to markedly decrease the skeletal muscle contraction compared to controls while simultaneous administration of vitamin E completely antagonized cadmium induced inhibitory effect on muscular contraction. The activity of acetylcholine esterase, Na+, K+-ATPase and 5'-nucleotidase in sciatic nerve of cadmium treated rats was significantly increased while vitamin E had no effect on cadmium induced changes in the activity of these enzymes. Concurrent administration of vitamin E also did not influence the elevated levels of cadmium in the sciatic nerve due to metal exposure. It is suggested that the antagonistic effect of vitamin E on cadmium induced inhibition on muscular contraction may be mediated through its antioxidative effect.
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