Effect of sub-lethal doses of albendazole on the fecundity of Dictyocaulus viviparus
1996
Osman, A.M.M. | Jacobs, D.E. | Fisher, M.A. | Pilkington, J.G. | Jones, P.A.
During an evaluation of the efficacy of prolonged low-dose albendazole therapy on nematode infections in calves, it was observed that a dose-rate of 2 mg kg-1 given daily for 10 days was highly effective at expelling Dictyocaulus viviparus, but smaller doses suppressed the faecal output of larvae without killing the lungworms. A more detailed study with four experimentally infected calves given 1 mg kg-1 day-1 for 10 days showed that faecal output of larvae ceased after six to eight days but resumed tour to six days after the withdrawal of the drug. The albendazole-induced sterility therefore reversible. A subsidiary study showed that the strain of parasite used was fully susceptible to albendazole.
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