Role of the trehalose carrier in dehydration resistance of Saccharomyces cerevisiae
1993
Eleutherio, E.C.A. | Araujo, P.S. de | Panek, A.D.
Yeast cells are well known for their ability to survive complete dehydration, a phenomenon that is directly, linked to the presence of the sugar trehalose in these cells. This sugar apparently endows the cells with the capacity to survive dehydration. Previous studies on in vitro models showed that trehalose must be present on both sides of the bilayer to stabilize dry membranes. The present report demonstrates that a specific trehalose carrier seems to enable the sugar to protect the yeast cell membrane by translocating trehalose from the cytosol to the extracellular environment. Saccharomyces cerevisiae mutant strains which lack the trehalose carrier did not survive after dehydration although they accumulated endogenous trehalose. Furthermore, when carrier mutants were dehydrated in the presence of exogenous trehalose the cells became more resistant showing increased survival.
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