Effect of dietary linoleic acid content on the distribution of phosphatidylcholine molecular species in rat plasma
1994
Koba, K. | Rozee-Baxter, L.A. | Lin, X. | Horrobin, D.F. | Huang, Y.S.
The effect of dietary linoleic acid on the profiles of phosphatidylcholine molecular species in rat plasma was investigated. On changing from an essential fatty acid-deficient state to an essential fatty acid sufficient state, the levels of molecular species containing 18:1 and 20:3n-9 were decreased, whereas those containing 18:2n-6 and 20:4n-6 were increased. However, the decrease was greater in the molecular species containing 20:3n-9 than in those containing 18:1, and the increase was greater in the molecular species containing 20:4n-6 than in those containing 18:2n-6. In rats fed the essential fatty acid deficient diet (containing 0.001 g/kg diet of linoleic acid), the major molecular species in plasma phosphatidylcholine was 16:0-8:1 and most of the molecular species have the total carbon chain length around 34. In rats fed the essential sufficient diet (containing 2.4 g/kg diet of linoleic acid), the major phosphatidylcholine molecular species was 18:0-20:4n-6, and most species had the total carbon chain length around 38. The changes of the molecular species profiles indicated that the metabolism of 18:1 to 20:3n-9 which was active in the essential fatty acid deficient rats was replaced with that of 18:2n-6 to 20:4n-6 in the essential fatty acid sufficient state.
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