Absorption and Effectiveness of Orally Administered Low Molecular Weight Collagen Hydrolysate in Rats
2010
Watanabe-Kamiyama, Mari | Shimizu, Muneshige | Kamiyama, Shin | Taguchi, Yasuki | Sone, Hideyuki | Morimatsu, Fumiki | Shirakawa, Hitoshi | Furukawa, Yuji | Komai, Michio
Collagen, a major extracellular matrix macromolecule, is widely used for biomedical purposes. We investigated the absorption mechanism of low molecular weight collagen hydrolysate (LMW-CH) and its effects on osteoporosis in rats. When administered to Wistar rats with either [14C]proline (Pro group) or glycyl-[14C]prolyl-hydroxyproline (CTp group), LMW-CH rapidly increased plasma radioactivity. LMW-CH was absorbed into the blood of Wistar rats in the peptide form. Glycyl-prolyl-hydroxyproline tripeptide remained in the plasma and accumulated in the kidney. In both groups, radioactivity was retained at a high level in the skin until 14 days after administration. Additionally, the administration of LMW-CH to ovariectomized stroke-prone spontaneously hypertensive rats increased the organic substance content and decreased the water content of the left femur. Our findings show that LMW-CH exerts a beneficial effect on osteoporosis by increasing the organic substance content of bone.
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