Adaptation of Glycolysis and Growth to Acetate in Sporolactobacillus sp. Y2-8
2012
Liu, Dong | Chen, Yong | Li, An | Zhao, Ting | Zhou, Tao | Li, Bingbing | Xie, Jingjing | Chen, Xiaochun | Bai, Jianxin | Hu, Yanan | He, Bingfang | Ying, Hanjie
Exogenous addition of a low concentration of acetate (2Â g/L sodium acetate) effectively decreased acetic acid excretion and lowered the ATP content in Sporolactobacillus sp. Y2-8 without any growth defect although the acetate could not be utilized at an initial glucose concentration of 150Â g/L. This induced an enhanced glycolytic flux with increased specific activities of hexokinase and phosphofructokinase, probably to compensate for the lowered efficiency of ATP production. However, with increasing concentrations (5Â g/L sodium acetate), acetate was utilized first before being produced again, causing a growth lag at the transition. Glucose consumption was also reduced at high acetate concentrations, resulting in decreased D-lactic acid production. These results demonstrate that acetate plays a significant role in regulating glycolysis and growth of Sporolactobacillus.
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